Generation of an Apoptotic Intracellular Peptide by γ-secretase Cleavage of Alzheimer's β-amyloid Precursor Protein
the Danish and British dementia ? Ben: BDI, Huntington's, Parkinson's, ALS, etc. So MANY
129 RESULTS
You searched Skovronsky et al., 1998
Sort By:
the Danish and British dementia ? Ben: BDI, Huntington's, Parkinson's, ALS, etc. So MANY
phosphorylation and subsequent degradation of beta-catenin (Takashima et al., 1998; Zhang et al., 1998). Niwa
periphery. See (Shibata et al. 2000, Demeester et al. 2000, Rebeck et al. 1998, Koudinov et al., 2002.)
subsequent improvement of cognitive function (Qu et al., 2001) reinforces the potential feasibility of HNSC
Mice lacking both PS1 and PS2 die before embryonic day 9 (Donoviel et al., 1999). PS1-/- mice, which
Ashford, Soultanian, et al., 1999. We did not examine axons. However, this discussion seems to be focusing
al., 2000; Weller et al., 1998). Moreover, in transgenic mice, virtually identical amyloid-associated
1992; Cogoni et al., 1996). Since its first description in animal cells (Fire et al., 1998), a growing
caused the sprouting. See our paper in J Neuroscience in November (Sheng et al., 2002). Milos Ikonomovic
need such a lesson and do have to depart). Pete Nelson Thanks for the chat, Gabrielle et al.; it was
See Harrison et al., 2003.] Stefan Lichtenthaler Gabrielle, this brings us to the question of
Indirect evidence is there. APP translation is regulated by iron (Rogers et al., 2002). Alexei Koudinov
One was from my colleague Chuck Murry (see Murry et al., 2004), and the other involved Irv Weissman
but not by apoptosis (we discussed this in Science/Nature several years ago, see Perry et al 1998 and
decreases in proteasome activity in AD (Keller et al., 2000 and Keck et al., 2003, but has anyone looked
Have a topic idea for a webinar? We would love to hear it. Send an email to webinars [at] alzforum [dot] org.